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Humoral immune responses to Mycoplasma hyopneumoniae in sows and offspring following an outbreak of mycoplasmosis
Authors:Per Wallgren, G  ran B  lske, Stig Gustafsson, Sigbrit Mattsson,Caroline Fossum
Affiliation:

a National Veterinary Institute, Box 7073, 750 07 Uppsala, Sweden

b Bällsta, Odensvi, 731 93 Köping, Sweden

c Department of Veterinary Microbiology, Division of Immunology, Swedish University of Agricultural Sciences, BMC Box 588, 751 23 Uppsala, Sweden

Abstract:Previously healthy sows, seropositive to Mycoplasma hyopneumoniae, developed clinical signs of mycoplasmosis, as well as increasing amounts of antibodies to M. hyopneumoniae during an outbreak of the disease in a herd. During the early phase of the outbreak, young piglets (2 weeks) with maternal antibodies remained healthy while older seronegative piglets (4–7 weeks) developed the disease. The duration of the maternal antibodies to M. hyopneumoniae varied between litters and was related to the amount of antibodies in the serum of the dam. In sows, the level of serum antibodies decreased continuously from 4 weeks ante partum to partus, and the level of antibodies in the whey of colostrum was comparable to that in serum 4 weeks ante partum. After loss of maternal antibodies to M. hyopneumoniae, seropositive animals were not found among piglets younger than 9 weeks. Therefore peripheral blood mononuclear cells (PBMC) were collected from various age categories of piglets in order to measure the ability to produce antibodies to M. hyopneumoniae in vitro. PBMC obtained from piglets aged 1 and 3 weeks produced few antibodies to M. hyopneumoniae. Significantly higher levels of antibodies to M. hyopneumoniae were produced by PBMC obtained from pigs aged 5–9 weeks. Thus, the ability of PBMC to produce antibodies to M. hyopneumoniae in vitro seemed to be age-dependent.
Keywords:Pig   Mycoplasma hyopneumoniae   Maternal immunity   Immunity   Antibody   Age   Piglet   Sow
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