Protein adsorption on nano-scaled, rippled TiO2 and Si surfaces |
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Authors: | Jana Sommerfeld Jessica Richter Raphael Niepelt Stefanie Kosan Thomas F Keller Klaus D Jandt Carsten Ronning |
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Institution: | Institute of Solid State Physics, Friedrich Schiller University, Jena, Germany. jana.sommerfeld@uni-jena.de |
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Abstract: | We synthesized nano-scaled periodic ripple patterns on silicon and titanium dioxide (TiO(2)) surfaces by xenon ion irradiation, and performed adsorption experiments with human plasma fibrinogen (HPF) on such surfaces as a function of the ripple wavelength. Atomic force microscopy showed the adsorption of HPF in mostly globular conformation on crystalline and amorphous flat Si surfaces as well as on nano-structured Si with long ripple wavelengths. For short ripple wavelengths the proteins seem to adsorb in a stretched formation and align across or along the ripples. In contrast to that, the proteins adsorb in a globular assembly on flat and long-wavelength rippled TiO(2), but no adsorbed proteins could be observed on TiO(2) with short ripple wavelengths due to a decrease of the adsorption energy caused by surface curvature. Consequently, the adsorption behavior of HPF can be tuned on biomedically interesting materials by introducing a nano-sized morphology while not modifying the stoichiometry/chemistry. |
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