| 竹红菌甲素固体分散体的制备及溶解性的研究 |
| |
| 引用本文： | 安红波,张爽,蔡亚平,常晓慧.竹红菌甲素固体分散体的制备及溶解性的研究[J].黑龙江八一农垦大学学报,2011,23(4):38-42. |
| |
| 作者姓名： | 安红波 张爽 蔡亚平 常晓慧 |
| |
| 作者单位： | 黑龙江八一农垦大学生命科学技术学院,大庆,163319 |
| |
| 摘 要： | 采用研磨法，以聚乙二醇6000为载体，将竹红菌甲素制备为固体分散体，增加其在水溶液中的溶解度，提高其生物利用度。采用紫外-可见分光光度计和荧光分光光度计分别测定竹红菌甲素-聚乙二醇6000固体分散体的吸光度和荧光强度。通过正交试验设计的方差分析，得到该固体分散体的最优制备条件：药物和载体的比例（mg·mg-1）为1：1...
|
| 关 键 词： | 竹红菌甲素 固体分散体 溶解性 |
Preparation and Dissolution Properties of Solid Dispersion of Hypocrellin A |
| |
| An Hongbo,Zhang Shuang,Cai Yaping,Chang Xiaohui.Preparation and Dissolution Properties of Solid Dispersion of Hypocrellin A[J].Journal of Heilongjiang August First Land Reclamation University,2011,23(4):38-42. |
| |
| Authors: | An Hongbo Zhang Shuang Cai Yaping Chang Xiaohui |
| |
| Institution: | An Hongbo,Zhang Shuang,Cai Yaping,Chang Xiaohui(College of Life Science and Technology,Heilongjiang Bayi Agricultural University,Daqing 163319) |
| |
| Abstract: | Objective Polyethylene glycol 6000 is the carrier material with grinding method.The solid dispersions of Hypocrellin A(HA) were prepared with Polyethylene glycol 6000 as the carrier material in grinding method to increase its solubility in water solution and improve HA bioavailability.Methods: The absorbency and fluorescence intensity of Hypocrellin A-PEG 6000 were respectively determined with UV-vis spectrophotometer and fluorescence spectrophotometer.Results: By orthogonal experimental design and analysis... |
| |
| Keywords: | hypocrellin a solid dispersions solubility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
