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Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth |
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| Authors: | Khoobchandani M Ganesh N Gabbanini S Valgimigli L Srivastava M M |
| Affiliation: | a Department of Chemistry, Dayalbagh Educational Institute, Agra 282110, India;b Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, 422001, India;c R&D Department, B&C s.r.l, Via C. Monteverdi 49, 47100 Forlì Italy;d University of Bologna, Department of Organic Chemistry “A. Mangini”, Via S Giacomo 11, 40126 Bologna, Italy |
| Abstract: | Solvent extracts from the aerial and root parts and seed oil from E. sativa (rocket salad) were assayed for anticancer activity against melanoma cells. The seed oil (isothiocyanates rich) significantly (p < 0.01) reduced the tumor growth comparable to the control. Remarkably, the seed oil inhibited melanoma growth and angiogenesis in mice without any major toxicity. The findings qualify seed oil for further investigations in the real of cancer prevention and treatment. |
| Keywords: | Eruca sativa Isothiocyanates Melanoma Apoptosis UPLC-ESI-MS/MS |
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