| 微生物浊度法与管碟法测定吉他霉素效价的比较研究 |
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| 引用本文： | 徐嫄,赵晖.微生物浊度法与管碟法测定吉他霉素效价的比较研究[J].中国兽药杂志,2016,50(11):31-33. |
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| 作者姓名： | 徐嫄 赵晖 |
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| 作者单位： | 中国兽医药品监察所,中国兽医药品监察所 |
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| 摘 要： | 为比较微生物浊度法和管碟法测定吉他霉素效价,以《中国药典》(2015年版)吉他霉素抗生素微生物检定法浊度法和《中国兽药典》(2010年版)吉他霉素抗生素微生物检定法管碟法为依据测定一批吉他霉素效价。结果显示:浊度法测定效价平均值为1691 U/mg,RSD为0.9%;管碟法测定效价平均值为1687 U/mg,RSD为1.0%,两种方法测定结果无显著性差异(P0.05)。本实验表明,浊度法测定吉他霉素效价与管碟法相比更加快速、便捷,而且可避免吉他霉素多组分的影响因素。
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| 关 键 词： | 浊度法 管碟法 吉他霉素 效价 |
| 收稿时间： | 2016/7/31 0:00:00 |
| 修稿时间： | 2016/10/20 0:00:00 |
Comparison of the Antibiotic Potency of Kitasamycin by Turbidimetric Method and Diffusion Method |
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| Institution: | China Institute of Veterinary Drug Control, |
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| Abstract: | In order to compare turbidimetric method with diffusion method for measuring of antibiotic potency of kitasamycin, a bath of kitasamycin potency was measured by turbidimetric method according to quality standards in Chinese Pharmacopoeia 2015 version and diffusion method according to quality standards in Chinese Veterinary Pharmacopoeia 2010 version. Results of potency average were 1691 U/mg by turbidimetric method with RSD of 0.9% and 1687 U/mg by diffusion method with RSD of 1.0%. There was no significant difference as compared (P>0.05). Results showed that compared with diffusion method, turbidimetric method is not only more rapid and convenient, but also could avoid cross-influence of the ingredients in kitasamycin. |
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| Keywords: | turbidimetric method diffusion method Kitasamycin potency |
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