Statistical Evaluation of Test Accuracy Studies for Toxoplasma gondii in Food Animal Intermediate Hosts |
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Authors: | I A Gardner M Greiner J P Dubey |
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Institution: | 1. Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA;2. Federal Institute for Risk Assessment, Epidemiology, Biostatistics and Mathematical Modelling Unit, Berlin, Germany;3. United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, MD, USA |
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Abstract: | The availability of accurate diagnostic tests is essential for the detection and control of Toxoplasma gondii infections in both definitive and intermediate hosts. Sensitivity, specificity and the area under the receiver‐operating characteristic (ROC) curve are commonly used measures of test accuracy for infectious diseases such as toxoplasmosis. These test performance characteristics are important considerations when selecting from among a group of tests for a specific testing purpose. In this study, we reviewed statistical approaches to evaluation of tests for toxoplasmosis with and without a gold‐standard (reference) test, including use of ROC analysis and likelihood ratios which retain the diagnostic information inherent in a quantitative test result. We use previously published data from a comparison of the accuracy of serological tests for swine toxoplasmosis to demonstrate suggested methods of data analysis. We make recommendations for statistical analysis and reporting of test evaluation studies for T. gondii in food animals based on our own experiences and those of others. |
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Keywords: | Diagnostic test evaluation test accuracy receiver‐operating characteristic analysis likelihood ratios latent class analysis Toxoplasma gondii |
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