Anti‐allergic effects of Lactobacillus crispatus KT‐11 strain on ovalbumin‐sensitized BALB/c mice |
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Authors: | Keisuke TOBITA Hiroyuki YANAKA Hajime OTANI |
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Institution: | 1. Interdisciplinary Graduate School of Science and Technology, Shinshu University, Minamiminowa;2. Kitii Co., Ltd, Saiwai, Kawasaki, Japan |
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Abstract: | In this study, we investigated the effects of oral ingestion of Lactobacillus crispatus KT‐11 strain (KT‐11) on the immune response in an allergic rhinitis mouse model, ovalbumin (OVA)‐sensitized BALB/c mice. Sneezing activity in mice that were administered a KT‐11‐supplemented diet was significantly lower than that in mice administered a KT‐11‐free diet (control diet) at age 11 weeks. We found that serum OVA‐specific immunoglobulin E (IgE) levels and total number of interleukin (IL)‐4+CD4+ spleen cells in mice that were administered a KT‐11‐supplemented diet were significantly lower than in mice administered a control diet. The ratio of spleen interferon‐γ+CD4+/IL‐4+CD4+ cells was higher in the mice administered the KT‐11‐supplemented diet compared to that in mice administered the control or L. rhamnosus GG‐supplemented diet. In contrast, the number of CD11b+CD80+ and FcεRIα+CD117+ cells was significantly lower in mice administered the KT‐11‐supplemented diet. These results suggested that KT‐11 reduced OVA‐induced allergic symptoms in BALB/c mice via the adjustment of the T helper type 1/T helper type 2 balance, and a decrease in the number of antigen‐presenting cells and high affinity IgE receptor‐positive mast cells. |
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Keywords: | anti‐allergic effect antigen‐presenting cells Lactobacillus crispatus KT‐11 mast cells Th1/Th2 balance |
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