Acquired myasthenia gravis and cholangiocellular carcinoma in a dog |
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Authors: | L J Krotje A S Fix A D Potthoff |
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Affiliation: | Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011. |
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Abstract: | Acquired myasthenia gravis and cholangiocellular carcinoma were diagnosed in a 7-year-old English Setter referred because of forelimb lameness, exercise-induced weakness, and fever. Three months earlier, the dog had had a pleuropulmonary infection caused by a Fusobacterium sp. The concurrent development of myasthenia gravis and cholangiocellular carcinoma in this dog may be explained by a paraneoplastic syndrome, although it is unproven. The cholangiocellular carcinoma may have possessed an acetylcholine receptor-like antigen on the tumor surface, which induced autoantibodies to cross-react with acetylcholine receptors at the neuromuscular junction. |
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