| 单股正链RNA病毒基因组3＇非编码区功能 |
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| 引用本文： | 刘长龙,袁世山. 单股正链RNA病毒基因组3＇非编码区功能[J]. 中国兽医寄生虫病, 2010, 18(3): 76-81 |
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| 作者姓名： | 刘长龙 袁世山 |
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| 作者单位： | 中国农业科学院上海兽医研究所,上海,200241 |
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| 摘 要： | 单股正链RNA病毒数量众多,对人、动物和植物造成很大的危害。病毒基因组3＇末端都具有一段非编码区,基因组3＇非编码区在病毒的复制过程中发挥着重要的作用。本文简单介绍了单股正链RNA病毒基因组3＇非编码区结构的预测、测定和功能的研究方法,并重点概括了不同单股正链RNA病毒3＇非编码区一级序列、茎-环结构、假结体、TLS等结构在病毒基因组的复制、转录和翻译中的调控作用以及目前存在的问题。
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| 关 键 词： | 3＇非编码区（3＇UTR） RNA复制 亚基因组RNA转录 翻译 茎-环结构 假结体 |
FUNCTIONS OF THE 3' UNTRANSLATED REGIONS OF POSITIVE-STRAND RNA VIRAL GENOMES |
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| LIU Chang-long,YUAN Shi-shan. FUNCTIONS OF THE 3' UNTRANSLATED REGIONS OF POSITIVE-STRAND RNA VIRAL GENOMES[J]. Chinese Journal of Veterinary Parasitology, 2010, 18(3): 76-81 |
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| Authors: | LIU Chang-long YUAN Shi-shan |
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| Affiliation: | (Shanghai Veterinary Research Institute,CAAS Shanghai 200241,China) |
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| Abstract: | The 3＇ untranslated region of the positive-sense single-strand RNA viruses,which are important pathogens of human,animal and plant,plays important role in the virus replication.The primary sequence of the positive-sense single-stranded RNA virus 3＇UTR and the high order structure including stem-loop structure,pseudoknot,tRNA-like structure play regulatory role in viral genome replication,transcription and translation.The research methods and progress in 3＇ UTR of different single-stranded plus RNA viruses are reviewed in this article. |
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| Keywords: | 3＇ untranslated region（3＇ UTR） RNA replication subgenomic RNA transcription translation stem-loop structure pseudoknot structure |
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