Tissue-specific enhancement of xenobiotic detoxification enzymes in mice by dietary rosemary extract |
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Authors: | Keith W Singletary Joan T Rokusek |
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Institution: | (1) Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois, 467 Bevier Hall, 905 South Goodwin Avenue, 61801 Urbana, IL, USA |
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Abstract: | Plant foods contain nutritive and minor, nonnutritive components capable of inhibiting experimental carcinogenesis. Many of
these cancer-protective extracts act by enhancing the activities of enzymes that can detoxify reactive substances. In the
present study an extract of the spice plant rosemary was fed at concentrations of 0.3% and 0.6% (by weight) for 4 weeks to
female A/J mice prior to determination of the activities of the detoxification enzymes glutathione-S-transferase (GST) and
NAD(P)H: quinone reductase (QR) in lung, liver and stomach. Liver activities of GST and QR, and stomach GST activity were
significantly increased in animals fed diets containing rosemary extract. However, diets supplemented with rosemary extract
did not affect lung GST and QR activities. These results indicate that components of rosemary extract have the potential to
protect mouse liver and stomach from carcinogenic or toxic agents. |
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Keywords: | Rosemary Glutathione-S-transferase Quinene reductase |
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