| 朊蛋白构象改变和种属突破机制的研究进展 |
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| 引用本文： | 张太翔,赵德明.朊蛋白构象改变和种属突破机制的研究进展[J].中国畜牧兽医,2006,33(11):68-71. |
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| 作者姓名： | 张太翔 赵德明 |
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| 作者单位： | 中国农业大学国家动物海绵状脑病实验室,北京,100094 |
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| 基金项目： | 国家自然基金(30571399,30500371)，教育部博士点基金(20050019031)资助 |
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| 摘 要： | 异常朊蛋白(P rP sc)是一种可引起人和动物传染性脑退化病的不含核酸的蛋白因子。P rP c是一个正常的蛋白,有正常的生理功能,主要分布于神经元表面,属于肌醇磷脂锚蛋白类。由P rP c向P rP sc转变即产生疾病。作者简单介绍了正常和异常朊蛋白结构、功能、构象改变及朊病毒种属屏障的研究进展,并提出了目前尚待研究的问题。
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| 关 键 词： | 朊蛋白 种属屏障 结构 构象改变 |
| 文章编号： | 1671-7236（2006）11-0068-03 |
| 收稿时间： | 2006-03-16 |
| 修稿时间： | 2006年3月16日 |
The Advance of Pron Protein Conformation Changing and Crossing Species Barrier Mechanism |
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| ZHANG Tai-xiang,ZHAO De-ming.The Advance of Pron Protein Conformation Changing and Crossing Species Barrier Mechanism[J].China Animal Husbandry & Veterinary Medicine,2006,33(11):68-71. |
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| Authors: | ZHANG Tai-xiang ZHAO De-ming |
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| Institution: | Laboratory of National Animal TSE, College of Veterinary Medicine, China Agricultural Unversity, Beijing 100094, China |
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| Abstract: | Prion was a protein which could cause the transmissible neurodegenerative diease of human and animal,which did not include the nuclear.PrPc was normal protein which had normal foundation,contributing in the surface of neuron,belonging glycoinositol phospholipids.It was PrPc changed into PrPsc that cause these disease.This review introduced the advance of the structure,foundation,conformation changing of normal and non-normal prion protein and species barrier of prion,putting forward to the question be researched now. |
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| Keywords: | prion protein species barrier structure conformation changing |
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