|
|||||
|
|
Fabrication of electrospun antimicrobial nanofibers containing metronidazole using nanospider technology |
|
| Authors: | Mohamed H. El-Newehy Salem S. Al-Deyab El-Refaie Kenawy Ahmed Abdel-Megeed |
| Affiliation: | 1. Petrochemical Research Chair, Department of Chemistry, College of Science, King Saud University, 2455, Riyadh, 11451, Saudi Arabia 2. Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt 3. Department of Botany and Microbiology, College of Science, King Saud University, 2455, Riyadh, 11451, Saudi Arabia 4. Department of Plant Protection, Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria, 2153, Egypt |
| Abstract: | Nanospider technology as a modified electrospinning technique was used for the fabrication of electrospun nanofibers based on poly(vinyl alcohol) (PVA)/poly(ethylene oxide) (PEO) blend as drug delivery system (DDS) for metronidazole (MTZ) as an antimicrobial drug. Electrospun PVA/PEO/MTZ composite nanofibers were stabilized against disintegration in water by heating in oven at 110°C, or by soaking in isopropyl alcohol for 6 hrs. Incorporation of MTZ into electrospun nanofibers was confirmed by SEM, FT-IR spectra and TGA. The drug release results showed that the burst release was suppressed with stabilized electrospun nanofibers compared with non-stabilized ones. Electrospun PVA/PEO/MTZ composite nanofibers exhibited remarkable antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, Penicillium notatum and Aspergillus flavus which varies with the species of the tested organisms. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |