Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense |
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| Authors: | Dos Santos J G Blanco M M Do Monte F H M Russi M Lanziotti V M N B Leal L K A M Cunha G M |
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| Affiliation: | 1. Department of Molecular and Cellular Physiology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;2. Department of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;3. Department of Cell Biology and Molecular Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;4. Department of Immunology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;1. Centro de Investigación y Desarrollo en Criotecnología de los Alimentos (CIDCA), CONICET, Fac. Cs. Exactas (UNLP), 47 y 116, La Plata 1900, Argentina;2. Instituto Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Spanish National Research Council (CSIC), José Antonio Novais 10, 28040 Madrid, Spain |
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| Abstract: | The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rota-rod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. In the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death. On the contrary, in the elevated plus maze, the doses 50, 100 and 150 mg/kg did not affect the evaluated parameters. Thus, HAE presented anticonvulsant and sedative effects. Phytochemical analysis detected the presence of tannins, saponins, sterols and flavonoids. |
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