Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells |
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| Authors: | M I Wahl T O Daniel G Carpenter |
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| Institution: | Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232. |
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| Abstract: | A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis. |
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