Antimicrobial ent-pimarane diterpenes from Viguiera arenaria against Gram-positive bacteria |
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| Authors: | Thiago Souza Porto, Niege A.J.C. Furtado, Vladimir C.G. Heleno, Carlos H.G. Martins, Fernando B. Da Costa, Marcela E. Severiano, Aline N. Silva, Rodrigo C.S. Veneziani,S rgio R. Ambr sio |
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| Affiliation: | aNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil;bDepartamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil |
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| Abstract: | The dichloromethane crude extract from the roots of Viguiera arenaria (VaDRE) has been employed in an antimicrobial screening against several bacteria responsible for human pathologies. The main diterpenes isolated from this extract, as well as two semi-synthetic pimarane derivatives, were also investigated for the pathogens that were significantly inhibited by the extract (MIC values lower than 100 μg mL− 1). The VaDRE extract was significantly active only against Gram-positive microorganisms. The compounds ent-pimara-8(14),15-dien-19-oic acid (PA); PA sodium salt; ent-8(14),15-pimaradien-3β-ol; ent-15-pimarene-8β,19-diol; and ent-8(14),15-pimaradien-3β-acetoxy displayed the highest antibacterial activities (MIC values lower than 10 μg mL− 1 for most pathogens). In conclusion, our results suggest that pimaranes are an important class of natural products for further investigations in the search of new antibacterial agents. |
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| Keywords: | Pimarane diterpenes Antimicrobial activity Viguiera arenaria Gram-positive bacteria |
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