| 高纯度大豆低聚肽药代动力学与急性毒性试验 |
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| 引用本文： | 高长城,马红霞,李煜馨,宛淑芳,周书华,刘辉. 高纯度大豆低聚肽药代动力学与急性毒性试验[J]. 吉林农业大学学报, 2007, 29(2): 200-202 |
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| 作者姓名： | 高长城 马红霞 李煜馨 宛淑芳 周书华 刘辉 |
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| 作者单位： | 长春大学吉林省农产品加工生物技术重点实验室,长春,130022;吉林农业大学动物科学技术学院,长春,130118;国家大豆深加工技术研究推广中心,长春,130022 |
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| 摘 要： | 研究了以“高温豆粕”为原料生产的高纯度大豆低聚肽在长白猪体内的药代动力学。结果表明:灌服后5 min进入血液,达峰时间10 min,半衰期为12 h。高纯度大豆低聚肽在最大给药剂量(按体重)30 g/kg时,无中毒现象出现,未测出半数致死量。急性毒性试验证明高纯度大豆低聚肽无毒。
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| 关 键 词： | 大豆肽 高纯度大豆低聚肽 NSI值 溶解度 药代动力学 毒性试验 |
| 文章编号： | 1000-5684（2007）02-0200-03 |
| 修稿时间： | 2006-06-292006-10-11 |
Metabolism Kinetics and Acute Toxicity of Highly Purified Soybean Oligopeptides |
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| GAO Chang-cheng,MA Hong-xia,LI Yu-xin,WAN Shu-fang,ZHOU Shu-hua,LIU Hui. Metabolism Kinetics and Acute Toxicity of Highly Purified Soybean Oligopeptides[J]. Journal of Jilin Agricultural University, 2007, 29(2): 200-202 |
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| Authors: | GAO Chang-cheng MA Hong-xia LI Yu-xin WAN Shu-fang ZHOU Shu-hua LIU Hui |
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| Abstract: | Metabolism kinetics of highly purified soybean oligopeptides produced from high-temperature bean dregs in Changbai swine body was tested.The tests showed highly purified soybean oligopeptides could be detected in swine blood at 5 min after irrigation of stomach,and arrived at peak value at 10 min.Half life of highly purified soybean oligopeptides in swine was about 12 h.Mouse acute toxicity tests showed highly purified soybean oligopeptides could not be found to cause toxicity and half death rate could not be measured even when its dosage reached 30 g/kg. |
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| Keywords: | soybean peptide highly purified soybean oligopeptide NSI value solubility metabolism kinetics toxicity. |
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