Pharmacokinetics of ketamine HC1 and metabolite I in the cat: a comparison of i.v., i.m., and rectal administration |
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| Authors: | R M HANNA R E BORCHARD S L SCHMIDT |
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| Institution: | Department of Veterinary & Comparative Anatomy, Pharmacology, Physiology, College of Veterinary Medicine, Washington State University, Pullman. |
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| Abstract: | Ketamine HCl 2-(o-chlorophenyl)-2-(methylamino) cyclohexanone HCl] concentrations in whole blood were used to study the pharmacokinetics of i.v., i.m., and rectal administrations, at a dose of 25 mg/kg, in normal domestic cats. Absorption was rapid with both the i.m. and rectal routes. Systemic availability was 51% (SEM 10) for the i.m. dose and 43.5% (SEM 6.1) for the rectal dose. The first-pass effect had a minimal influence on the metabolism of ketamine HCl administered rectally. The elimination rate constant (beta) of the drug was statistically similar in the i.v., i.m., and rectal groups, at a 95% level of significance (P less than 0.05). At the dosage rates studied, ketamine HCl produced an anesthetic effect in the cat following i.v., i.m. and rectal administration. |
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