The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness |
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| Authors: | Saint André Amélie v Blackwell Nathan M Hall Laurie R Hoerauf Achim Brattig Norbert W Volkmann Lars Taylor Mark J Ford Louise Hise Amy G Lass Jonathan H Diaconu Eugenia Pearlman Eric |
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| Institution: | Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA. |
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| Abstract: | Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells. |
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