| 氟虫腈偶联磷酸酯及氨基甲酸酯类化合物的合成及生物活性 |
| |
| 引用本文： | 马远,杨文,李德亮,徐汉虹.氟虫腈偶联磷酸酯及氨基甲酸酯类化合物的合成及生物活性[J].农药学学报,2011,13(5):531-534. |
| |
| 作者姓名： | 马远 杨文 李德亮 徐汉虹 |
| |
| 作者单位： | 1.天然农药与化学生物学教育部重点实验室/华南农业大学 昆虫毒理研究室,广东 510642 |
| |
| 基金项目： | 国家自然科学基金(30971045);广东省自然科学基金(8251064201000001). |
| |
| 摘 要： | 依据活性亚结构拼接原理,合成了6个新型含有磷酸酯和氨基甲酸酯结构片段的氟虫腈衍生物,其结构经核磁共振氢谱和碳谱、电喷雾质谱(ESI-MS)以及元素分析确证。初步生物活性及毒性测定结果表明:目标化合物对斜纹夜蛾 Spodoptera litura 和亚洲玉米螟 Ostrinia furnacalis 幼虫均具有良好的杀虫活性,其中化合物 1和2 对亚洲玉米螟幼虫的杀虫活性优于氟虫腈,LC50值分别为0.85和2.01 μ g/mL;目标化合物对意大利蜜蜂 Apis mellifera L.的毒性均显著低于氟虫腈。
|
| 关 键 词： | 氟虫腈 磷酸酯 氨基甲酸酯 杀虫活性 毒性 |
| 收稿时间： | 2011/5/16 0:00:00 |
| 修稿时间： | 6/4/2011 12:00:00 AM |
Synthesis and bioactivity of fipronil derivatives modified with phosphate esters and carbamates |
| |
| MA Yuan,YANG Wen,LI De-liang and XU Han-hong.Synthesis and bioactivity of fipronil derivatives modified with phosphate esters and carbamates[J].Chinese Journal of Pesticide Science,2011,13(5):531-534. |
| |
| Authors: | MA Yuan YANG Wen LI De-liang and XU Han-hong |
| |
| Institution: | 1.Key Lab of Natural Pesticide and Chemical Biology,Ministry of Education/Lab of Insect Toxicology, South China Agricultural University,Guangzhou 510642,China |
| |
| Abstract: | Six novel compounds were synthesized by incorporating phosphate esters and carbamates into fipronil through substructure link principle.Their structures were confirmed by 1H NMR and 13C NMR spectra,ESI-MS,as well as elemental analysis.The results of preliminary insecticidal activity tests and toxicity tests showed that the novel compounds possessed good activity against Spodoptera litura and Ostrinia furnacalis.In particular,compounds 1 and 2 exhibited better activity against O.furnacalis than fipronil,LC50... |
| |
| Keywords: | fipronil phosphate ester carbamate insecticidal activity toxicity |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《农药学学报》浏览原始摘要信息 |
| 点击此处可从《农药学学报》下载免费的PDF全文 |
