小鼠和大鼠口服氢溴酸槟榔碱的急性毒性试验

研究口服氢溴酸槟榔碱对小鼠和大鼠的急性毒性,为将其研究开发为新药奠定基础,为临床用量的确定提供科学依据.选用昆明种小鼠及SD大鼠,经口灌胃一次给药,统计死亡率,用改良寇氏法计算半数致死量(LD50),并观察毒性作用.结果氢溴酸槟榔碱对小鼠的口服LD50为691.83 mg/kg,95%可信区间为642.92 mg/kg～744.47 mg/kg;对SD大鼠的口服LD50为2 054 mg/kg,95%可信区间为1 908 mg/kg～2 210 mg/kg.表明氢溴酸槟榔碱属于低毒性的药物,按1 mg/kg～5 mg/kg临床应用非常安全.

Acute Toxicity of Arecoline Hydrobromide in Mice and Rat in Taking Orally

The acute oxicity test of Arecoline hydrobromide in mice and rat in taking orally was carried out in order to establish base for further research and development.then provid science foundation for clinical dosage.The toxic effect was observed and the LD50 were calculated by Karber method. The results suggested that LD50 of Arecoline hydrobromide in rat was 2 054 mg/kg,and 95% average incredible range of its LD50 was 1 908 mg/kg~2 210 mg/kg;and LD50 of Arecoline hydrobromide in mice was 691.83 mg/kg,and 95% average incredible range of its LD50 was 642.92 mg/kg~744.47 mg/kg.The results suggested that Arecoline hydrobromide is the drug of low toxicity,1 mg/kg ~5 mg/kg clinical application very safety.