The antihistaminic chlorpheniramine inhibitsin vitro growth of several fungi isolated from harvested fruits |
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| Authors: | Torés Juan Antonio González María Dolores Pozo Eva Urdiales José Luis Medina Miguel Ángel Sánchez-Jiménez Francisca |
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| Institution: | (1) Estatión Experimental “La Mayora”, C.S.I.C., 29750 Algarrobo-Costa, Málaga, Spain;(2) Laboratorio de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, 20701 Málaga, Spain |
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| Abstract: | Chlorpheniramine (CPA) is an antihistaminic that changes the conformation of DNA and inhibits polyamine biosynthesis in mammalian
cells. In the present work, we tested the effect of CPA on four genera of fungi species (Altemaria alternata, Botrytis cinerea, Cladosporium cladosporioides and threePenicillium spp.) grownin vitro. Similar growth inhibitions of these genera were produced by 0.5 raM iprodione, CPA and histidinol, but CPA was the most effective.
The CPA sensitivities of the twoB. cinerea strains were different. Putrescine did not restore the fungal growth inhibited by CPA. |
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| Keywords: | Chlorpheniramine histidinol iprodione benomyl harmaline polyamines |
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