Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity |
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| Authors: | Lena Olsn Ulf Bondesson Hans Brostrm Ulf Olsson Behnaz Mazogi Marie Sundqvist Hans Tjlve Carina Ingvast-Larsson |
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| Institution: | a Division of Pathology, Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden;b Division of Analytical Pharmaceutical Chemistry, Biomedical Centre, Uppsala University, Uppsala and Department of Chemistry, National Veterinary Institute, SE-751 89 Uppsala, Sweden;c Division of Medicine and Surgery, Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden;d Unit of Applied Statistics and Mathematics, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden;e Östra Greda Research Group, SE-387 91 Borgholm, Sweden |
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| Abstract: | Horses with insect bite hypersensitivity (IBH) have difficulty in completely avoiding allergens, so effective treatment options are required. A randomised, placebo controlled and double blinded field study was conducted to determine the pharmacokinetics and efficacy in reducing dermatitis of the antihistamine cetirizine given orally at 0.4 mg/kg twice daily for 3 weeks. The influence of protection blankets and stabling were also investigated.The estimated maximum plasma concentration (Cmax) and trough plasma concentration of cetirizine were 135 ng/mL and 18 ng/mL, respectively. There was no difference in dermatitis reduction between the treatment and placebo groups (P = 0.77). The findings indicated that cetirizine was of no apparent benefit in treating IBH at the dose rate tested. The use of blankets and stabling were shown to have favourable influence on the dermatitis (P < 0.05) and may be the preferred options to prevent this condition. |
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| Keywords: | Horse Antihistamine Cetirizine Pharmacokinetics Insect bite hypersensitivity |
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