Assessment of serotonin in serum,plasma, and platelets of aggressive dogs |
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| Authors: | Marta León Belén Rosado Sylvia García-Belenguer Gema Chacón Ainara Villegas Jorge Palacio |
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| Institution: | 1. Laboratorios Merial, S.A. Servicio Técnico-Animales de Compañía, Barcelona, Spain;2. Departamento de Patología Animal, Universidad de Zaragoza, Zaragoza, Spain;1. IFM Biology, AVIAN Behaviour Genomics and Physiology group, Linköping University, Linköping 581 83, Sweden;2. Department of Military Studies, Military-Technology Division, Swedish National Defence College, Stockholm 115 93, Sweden;3. Swedish Armed Forces Dog Instruction Centre, Märsta 195 24, Sweden;1. Department of Veterinary Clinical and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark;2. Section for Epidemiology, Technical University of Denmark, National Veterinary Institute, Frederiksberg, Denmark;1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907, USA;2. Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, VPTH, 785 Harrison Street, West Lafayette, IN 47907, USA;3. Fondation Barry, 1928 Martigny, Switzerland;1. Department of Psychology, Wright State University, Dayton, OH 45435, United States;2. Department of Behavioural Biology, University of Münster, Münster, Germany;3. Psychology Department, College of Wooster, Wooster, OH 44691, United States;1. Technical Institute of Education and Animal Control, São Paulo, Brazil;2. Department of Preventive Veterinary Medicine and Animal Health, Laboratory of Epidemiology and Biostatistics, University of São Paulo, São Paulo, Brazil;3. Department of Veterinary Medicine, Colombian Institute of Homeopathy, Bogotá, Colombia;4. Elemental Animal Inc., St Johnsville, New York;5. Department of Veterinary Medicine, Federal University of Paraná, Curitiba, Brazil;1. School of Veterinary Medicine and Science, The University of Nottingham, Leicester, UK;2. The Guide Dogs for the Blind Association, Berkshire, UK;3. Centre for Behavior and Evolution, Henry Wellcome Building, Newcastle University, Newcastle, UK |
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| Abstract: | Canine aggression is the most common reason for the referral of dogs to behavior practices. In addition, dog bites represent an important problem for public health and animal welfare. The serotonergic system is believed to play an important role in modulating aggression. The aim of the present study was (1) to assess the suitability of different types of blood samples for measuring circulating serotonin in canine clinical studies, and (2) to investigate the relationship between the serotonergic system and canine aggression. The assessment of serotonin was simultaneously carried out in serum, plasma, and platelets of 28 aggressive and 10 nonaggressive dogs with an enzyme immunoassay technique. The mean serotonin concentration in aggressive dogs was significantly lower than in nonaggressive dogs in all the assayed samples. These findings suggest an inverse relationship between the activity of the serotonergic system and canine aggression. Considering the simplicity of the methodology, the authors propose sampling serum as the most suitable method for measuring circulating serotonin in dogs. |
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