Allosteric mechanisms of signal transduction |
| |
Authors: | Changeux Jean-Pierre Edelstein Stuart J |
| |
Affiliation: | Receptors and Cognition, Institut Pasteur, 75724 Paris Cedex 15, France. changeux@pasteur.fr |
| |
Abstract: | Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|