Changes in blood pressure following escalating doses of phenylpropanolamine and a suggested protocol for monitoring |
| |
| Authors: | Gilad Segev Jodi L Westropp Chen Kulik Eran Lavy |
| |
| Institution: | School of Veterinary Medicine, the Hebrew University of Jerusalem, Israel, P.O. Box 12, Rehovot, 76100, Israel (Segev, Kulik, Lavy); Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA (Westropp). |
| |
| Abstract: | This prospective, cross-over, blinded study evaluated the effect of various doses of phenylpropanolamine (PPA) on blood pressure in dogs. Dogs were randomized to receive a placebo or 1 of 3 dosages of immediate release PPA, q12h for 7 days 1 mg/kg body weight (BW), 2 mg/kg BW, or 4 mg/kg BW] in a cross-over design. Blood pressure was recorded every 2 h, for 12 h, on days 1 and 7. There were significant increases in systolic, diastolic, and mean blood pressure following administration of PPA at 2 mg/kg BW and 4 mg/kg BW. A significant decrease in heart rate was also noted at all PPA dosages, but not in the placebo. Administration of PPA was associated with a dose response increase in blood pressure. Dosages of up to 2 mg/kg BW should be considered safe in healthy dogs. |
| |
| Keywords: | |
|
|
