Protein Z intron FG79A polymorphisms are not associated with coronary artery disease

AIM: To investigate the distribution of protein Z intron FG79A polymorphisms in Chinese and the associations with coronary artery disease (CAD). METHODS: 148 patients were performed selected coronary angiography and more than one major coronary vessel with at least 50% stenosis was defined as CAD. The control group consisted of 147 subjects. The protein Z intron FG79A polymorphisms were studied by polymerase chain reaction and restriction fragment length polymorphism and parts of PCR products were sequenced. RESULTS: Protein Z intron FG79A polymorphisms were first recovered in Chinese, and the frequencies of G and A alleles were 44.24% and 55.76%, respectively. The frequencies of two alleles were not significantly different between patients and controls. There was no significant difference in protein Z intron FG79A genotype distribution among patients with one, two or three stenosed vessels. No significant difference was found among the frequencies of the three genotypes between both acute coronary syndrome (ACS) and non-ACS. CONCLUSION: Protein Z intron FG79A polymorphisms are present in Chinese. Protein Z intron FG79A polymorphisms were not associated with CAD and ACS.