Protective effect of panaxadiols against brain injury induced by LPS through inhibiting NOS activity and p38 expression |
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| Authors: | SUN Ji-tong LI Hong-yan SU Jing KONG Xiao-xia YU Bin SUN Lian-kun KANG Jin-song |
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| Institution: | 1.Department of Information System and Information Management, School of Public Health, 2Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China. E-mail: kangjs@jlu.edu.cn |
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| Abstract: | AIM: To explore the protective effect of panaxadiols (PDS) on brain injury induced by endotoxin and its mechanism. METHODS: Rats were divided into control，LPS，LPS+dexamethasone (DEX) and LPS+PDS group, respectively. NOS activity, NO content and phosphorylated p38 expression in brain cortex were assayed 4 h after intravenous injection of LPS. RESULTS: NOS activity, NO content and phosphorylated p38 expression in brain cortex in LPS group were obviously higher than those in LPS group. NOS activity, NO content and phosphorylated p38 expression in brain cortex in LPS+DEX and LPS +PDS groups were obviously lower than those in LPS group. CONCLUSION: The protective effects of PDS against brain injury induced endotoxin may be related to decreasing NOS activity, NO content in the brain tissue, and this process is involved in p38MAPKs signal transduction. |
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| Keywords: | Lipopolysaccharides Ginseng Dexamethasone p38 MAP kinase Nitric-oxide synthase Nitric oxide |
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