Effect of astragalus polysaccharides on cholesterol efflux in THP-1 macrophage-derived foam cells |
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| Authors: | YANG Zhi-hong GONG Wei CHEN Feng-ling ZHOU Wen-bai ZHANG Shuo LI Lian-xi LIANG Wen-chang YANG Ye-hong HU Ren-ming |
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| Affiliation: | 1.Department of Endocrinology, Huashan Hospital, 2Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China. E-mail: renminghu@fudan.edu.cn |
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| Abstract: | AIM: To study the effect of astragalus polysaccharides (Aps) on cholesterol efflux in THP-1 macrophage-derived foam cells. METHODS: After exposed to Aps at different doses, cholesterol efflux and ABCA1 protein levels in cultured THP-1 macrophage-derived foam cells were determined by a γ counter and flow cytometry, respectively. RESULTS: Aps increased cholesterol efflux in THP-1 macrophage-derived foam cells with dose dependent pattern and resulted in an increase in the expression of ABCA1 protein in THP-1 macrophage-derived foam cells. CONCLUSION: The increase in cholesterol efflux by Aps might be related to the up-regulation of ABCA1. |
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