慢性冠心病患者肺炎衣原体血清抗体的检测

目的观察慢性冠心病与肺炎衣原体感染的关系.方法应用间接微量免疫荧光法测定慢性冠心病74例(冠心病组)与健康人72例(对照组)血清中肺炎衣原体IgG、IgM的抗体滴度.结果两组的血清肺炎衣原体IgG抗体滴度差异有非常显著性(P＜0.01),对照组与冠心病组肺炎衣原体总感染率分别为72%与100%,其中既往感染率分别为72%与80%,急性感率分别为0%与20%.结论慢性冠心病患者肺炎衣原体感染率增高,肺炎衣原体感染可能是冠心病发生的致病因素之一.

Detection of serum antibodies to Chlamydia pneumoniae in patients with chronic coronary heart disease

Objective:To observe the incidence of Chlamydia pneumoniae (Cpn)infection in patients with chronic coronary heart disease(CCHD).Methods:Serum IgG and IgM antibodies to Cpn were determined by indirect microimmunofluorescence assay in 74 patients with CCHD and 72 health controls.Results:The total infection rates in controls and patients were 72% and 100% respectively( P <0.01);among them,the previous infection rates were 72%and 80%,and the acute ones were 0% and 20%( P <0.01),respectively.The titre of IgG antibody was significantly higher in patinents than that in controls( P <0.01).Conclusion:The incidence of CP infection increases in patients with CCHD,and Cpn infection may be a risk factor in the development of CCHD.