Orthohepadnavirus infection in a neotropical bat (Platyrrhinus lineatus) |
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| Institution: | 1. Clinical Laboratory, Yunnan Provincial Infectious Diseases Hospital, 28 km away from Shi''an highway, Yunnan, Kunming, China;2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China;1. Department of Virology, Veterinary Research Institute, Brno, Czech Republic;2. Faculty of Science, Masaryk University, Brno, Czech Republic;3. Institute of Vertebrate Biology, Czech Academy of Sciences, Brno, Czech Republic;4. Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany;5. Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia;6. Charité Medical School, Berlin, Germany;7. Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany;8. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, ?eské Budějovice, Czech Republic;1. Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil;2. Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil;3. MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom;4. Faculty of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil |
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| Abstract: | Hepatitis B virus (HBV) is the prototype of the Orthohepadnavirus genus and represents an important cause of chronic hepatitis, liver cirrhosis, and hepatic cancer in humans worldwide. To verify the occurrence and genetic variability of orthohepadnavirus among neotropical bats, we tested 81 liver samples of New World bats from São Paulo State, Southeastern Brazil, collected during 2012. PCR, sequencing, and phylogenetic analysis of Surface/Polymerase and Core viral genes confirmed the occurrence of the first isolate of bat orthohepadnavirus detected in South America. These results may contribute to subsequent studies of the origin, variability, host species, and evolution of bat orthohepadnaviruses in South America. |
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| Keywords: | Bats Chiroptera Hepatitis B Virus Brazil |
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