Evaluation of some acute phase proteins in cattle naturally infected with Babesia bigemina |
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| Affiliation: | 1. Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;2. Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;1. Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran;2. Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;3. Razi Vaccine & Serum Research Institute, Agricultural Research, Education and Extension Organization, Mashhad, Iran;4. Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;5. Department of Microbiology, Faculty of Basic Sciences, Ardabil Branch, Islamic Azad University, Ardabil, Iran;6. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran;1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Medical Parasitology and Mycology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran;3. Department of Geography, Ardabil Branch, Islamic Azad University, Ardabil, Iran;4. Genetic Engineering and Biotechnology Research Institute University of Sadat City Sadat, Egypt;5. Department of Parasitology and Mycology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;6. Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran;7. Department of Medical Microbiology and Parasitology, College of Health Sciences, Bayero University, PMB 3011, Kano, Nigeria;8. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;9. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;10. Department of Basic Sciences of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran;11. Department of Parasitology, School of Allied Medical Sciences. Ilam University of Medical Sciences, Ilam, Iran;1. Department of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran;2. Department of Pathobiology, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran;1. Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, Anhui Science and Technology University, Fengyang, Anhui, China;2. College of Animal Science, Anhui Science and Technology University, Fengyang, China;3. Laboratory of Pork Quality and Safety Control, Ministry of Agriculture and Rural Affairs, Fengyang, Anhui, China;1. Bacterial Disease Laboratory, Federal University of Bahia, 500 Adhemar de Barros Av., Salvador, BA 40170-110, Brazil;2. Department of Preventive Veterinary Medicine and Animal Production of the School of Veterinary Medicine and Zootechny, Federal University of Bahia, 500 Adhemar de Barros Av., Salvador, BA 40170-110, Brazil;3. Laboratory of Immunology and Molecular Biology, Health Science Institute, Federal University of Bahia, Reitor Miguel Calmon Av., Salvador, BA 40140-100, Brazil |
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| Abstract: | Bovine babesiosis due to Babesia bigemina infection induces systemic inflammation, evidenced by increased sialic acid (SA) levels and declined cholinesterase activity. The current study was undertaken to assess further indicators of the systemic inflammation in the naturally infected cattle. To this end, serum levels of some selected acute phase-proteins (APPs) including serum amyloid A (SAA), haptoglobin (Hp), ceruloplasmin (Cp), and fibrinogen were measured. Additionally, sensitivity and specificity of the APPs were calculated by receiver operating characteristic curve. The correlation among APPs, SA and cholinesterase activity were also assessed. Our previous blood specimens were used to measure APPs. Briefly, the diseased animals were divided into two groups according to the parasitemia: 12 mildly (20 % <) and 8 severely (20 %>) infected animals. Moreover, 10 healthy animals as the control were included. The levels of all APPs were measured to be significantly elevated in a parasitemia burden-dependent fashion as compared to the control. Furthermore, all the APPs showed 100 % specificity, but only SAA and Cp had 100 % sensitivity. A strong and positive correlation was calculated between the APPs and SA; however, cholinesterase activity was inversely correlated with AAPs and SA. In conclusion, inflammatory reactions play a pivotal role in the pathogenesis of bovine babesiosis and APPs can be considered as the potential indicators of inflammation. |
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| Keywords: | Acute phase protein Cattle Inflammation |
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