Confocal laser scanning analysis of an equine oral mast cell tumor with atypical expression of tyrosine kinase receptor C-KIT |
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Authors: | Seeliger F Hess O Pröpsting M J Pröbsting M Naim H Y Kleinschmidt S Woehrmann T Germann P G Baumgärtner W |
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Affiliation: | Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany. frank.seeliger@altanapharma.com |
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Abstract: | A 20-year-old female horse showed a nodular, firm, focal ulcerated mast cell tumor at the right dorsobuccal face of the tongue. Histologically, the nonencapsulated tumor consisted of dense, infiltrating aggregates of well-differentiated, Cresyl violet-positive mast cells accompanied by numerous eosinophils. Furthermore, they exhibited a strong, diffuse, intracytoplasmatic immunohistochemical signal for tryptase and a faint membrane-associated and perinuclear signal for tyrosine kinase receptor KIT. Confocal laser scanning microscopy confirmed an aberrant spatial colocalization of KIT in the Golgi apparatus, which may be the result of a defective protein processing within the tumor cells. The tumor was not associated with a poor prognosis. |
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