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Serum and intratumoural GH and IGF-I concentrations: Prognostic factors in the outcome of canine mammary cancer |
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| Authors: | Felisbina L Queiroga Dolores Prez-Alenza Gema Silvan Laura Pea Carlos S Lopes Juan C Illera |
| Institution: | a Department of Animal Physiology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain;b CECAV, Department of Veterinary Sciences, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal;c Department of Animal Medicine, Surgery and Pathology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain;d Institute of Biomedical Sciences Abel Salazar, Largo Prof. Abel Salazar, 4099-003 Porto, Portugal |
| Abstract: | The biological implication of the growth hormone/insulin like growth factor-I (GH/IGF-I) axis in canine mammary tumours (CMT) has been recently demonstrated, however its clinical and prognostic implications are unknown. Our aim was to investigate its prognostic significance.Hormonal determinations were done by enzyme immunoassays techniques validated for canine species in serum and tumour tissue from 32 bitches with CMT and in serum and normal mammary tissue from 10 controls. Serum and tissular GH and IGF-I concentrations were significantly higher in the case of malignant tumour compared with benign and controls. GH and IGF-I elevated concentrations were significantly associated with tumour relapse and/or metastases during follow-up and in dogs with reduced survival times; however these parameters were not independent prognostic factors in multivariate analysis. This association demonstrates a link between high serum and intratumoural GH and IGF-I concentrations and a worse prognosis and opens the possibility to new anticancer endocrine therapies in dogs. |
| Keywords: | GH/IGF-I axis GH IGF-I Serum Tissue Enzyme immunoassay Canine mammary tumours Autocrine Breast cancer |
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