Angiogenic markers in canine lymphoma tissues do not predict survival times in chemotherapy treated dogs |
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| Authors: | Wolfesberger B Tonar Z Fuchs-Baumgartinger A Walter I Skalicky M Witter K Thalhammer J G Pagitz M Kleiter M |
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| Institution: | Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria. Birgitt.Wolfesberger@vetmeduni.ac.at |
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| Abstract: | Angiogenesis, which is essential for malignancies to progress, depends on various signalling proteins including vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR-1 and VEGFR-2). Microvessel density (MVD) is frequently used to evaluate angiogenesis. This study assessed the relationship between expression of VEGF, VEGFR-1 and VEGFR-2, MVD and the survival time in dogs with lymphoma. VEGF, VEGFR-1 and VEGFR-2 expression was evaluated immunohistochemically and microvessel profiles were counted in 34 lymphoma samples. Seventy-nine percent of the samples showed high VEGF expression and 62% were highly positive for VEGFR-1; VEGFR-2 immunoreactivity was mostly negative. Dogs treated with chemotherapy had a median survival time of 266days, but no significant relationships were found between overall survival time, MVD and expression of VEGF, VEGFR-1 or VEGFR-2. In this study, VEGF its receptors and the MVD were no prognostic factors in dogs with lymphoma. |
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