丙硫磷对乙酰胆碱酯酶的抑制能力及其毒力与药效研究*

以两种对称型有机磷杀虫剂倍硫磷和敌敌畏为对照，利用Ｅｌｌｍａｎ法测定了不对称有机磷杀虫剂丙硫磷（Ｐｒｏｔｈｉｏｆｏｓ）对体外乙酰胆碱酯酶（ＡｃｈＥ）的抑制能力，并对褐刺蛾（Ｓｅｔｏｒａｐｏｓｔｏｒ－ｎａｔａＨａｍｐｓｏｎ）进行了３种杀虫剂的触杀毒力测定和野外药效试验。结果表明，丙硫磷为弱的ＡｃｈＥ体外抑制剂，酶抑制能力与毒力和药效间无相关性，抑制能力最差的丙硫磷对褐刺蛾幼虫毒力最强，野外药效也最好。说明丙硫磷的三元不对称结构和特殊的毒效基团与其高效低毒的特点之间可能有着密切的联系。

Studies on the Inhibition of Prothiofos to Acetylcholinesterase and Its Toxicity and Field Effect to Setora postornata

A comparison was made between symmetrical organic phosphorus insecticidesfenthion and dichlorvos.This paper studied the inhibition effect of structure unsymmetricalorganic phosphorus insecticide prothiofos to acetylcholinesterase(AchE)by means of Ella-man's method,then measured the touching toxicity and field effect of the three insecticides tothe larva of Setora postornata.The result shows that the inhibition of prothiofos is the weak-est to AchE of house-fly,but its toxicity is the strongest to the larva of Setora postornata andits field effect is also the best among the three insecticides.The study indicates that there isprobably a relationship between the characteristics of higher effect and lower toxicity of pro-thiofos and its unsymmetrical structure and unique toxicity effect.