A new coumestan with immunosuppressive activities from Flemingia philippinensis |
| |
| Authors: | Li Li Deng Xueyang Zhang Lixia Shu Pan Qin Minjian |
| |
| Affiliation: | a Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;b Key Laboratory of Modern Chinese Medicines (Ministry of Education), China Pharmaceutical University, Nanjing 21009, China;c The Yunnan Branch, Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Jinghong 666100, China |
| |
| Abstract: | A new coumestan, 1,3,9-trihydroxy-8-methoxycoumestan, named flemicoumestan A 1 together with nine isoflavone-related compounds were isolated from the ethyl acetate extract of the roots of Flemingia philippinensis. Their structures were elucidated and confirmed by spectroscopic methods and literature data. Compounds 3 and 4 showed strong lymphocyte proliferation inhibitory activity with an IC50 value of 1.04-2.76 μM, and the low cytotoxicity with the CC50 value of 71.01 and 56.36 μM, respectively. |
| |
| Keywords: | Flemingia philippinensis Leguminosae Coumestan Piscigenin Immunosuppressive activity |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
