Ultrastructural study of Langerhans cells in equine insect hypersensitivity "Kasen" |
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| Authors: | Kurotaki T Narayama K Oyamada T Yoshikawa H Yoshikawa T |
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| Institution: | Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan. |
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| Abstract: | Ultrastructural features of Langerhans cells (LCs) of equine "Kasen" were studied. Electron microscopic observation revealed that LCs were dendritic and had irregular nuclear membranes. A number of Birbeck granules (Bgs) of various types were observed in the cytoplasm of LCs. In LCs in the upper stratum spinous, many Bgs were observed (Type 2 LC). LCs in the epidermo-dermal junction (EDJ) had a few Bgs, vesicles (multivesicular bodies) and highly electron-dense granular endosomes in the cytoplasm (Type 3 LC). Inactive LCs were also observed between the keratinocytes (Type 1 LC). Various types of LCs observed in the skin lesions of equine "Kasen" were interpreted as representing those that recognize, intake and process antigens. |
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