Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment |
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| Authors: | Gärtner Andrea Ohlendorf Birgit Schulz Dirk Zinecker Heidi Wiese Jutta Imhoff Johannes F |
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| Affiliation: | Kieler Wirkstoff-Zentrum at IFM-GEOMAR (Leibniz Institute of Marine Sciences), AmKiel-Kanal 44, 24106 Kiel, Germany. agaertner@ifm-geomar.de |
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| Abstract: | Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6 ‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines. |
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| Keywords: | macrolide Micromonospora deep sea natural product marine |
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