中药“复方黄金颗粒”治疗雏鸡人工感染法氏囊病效果观察

以非免疫健康雏鸡为靶动物,对中药＂复方黄金颗粒＂治疗人工感染法氏囊病雏鸡进行了系列研究。结果显示：①给药试验组与未给药感染对照组相比,天冬氨酸氨基转移酶（Ast）和丙氨酸氨基转移酶（Alt）差异显著（P〈0.05）,且Ast/Alt比值极显著（P〈0.01）低于阳性对照组,显著高于阴性对照组（P〈0.05）。②血清总蛋白（TP）、白蛋白（ALB）、球蛋白（GLB）在试验结束时试验组与阴性对照组相比差异显著（P〈0.05）。③给药试验组鸡死亡率显著低于未给药感染对照组（P〈0.05）,治愈率和有效率分别为90.0%和93.3%。④对治疗7 d未死的鸡只剖检,观察法氏囊损伤与肌肉出血程度,并对其病理变化程度进行了比较：给药试验组鸡的法氏囊损伤与肌肉出血程度病理分值均显著低于未给药感染对照组（P〈0.05）;对试验鸡法氏囊进行病理组织观察,中药＂复方黄金颗粒＂可以明显降低法氏囊病毒对法氏囊的损伤。结论：以枸杞子、菟丝子等中药制成的复方黄金颗粒剂对人工感染鸡传染性法氏囊病毒病具有显著的治疗效果。

Treatment effect of compound Huangjin granular on chickens artificially challenged with IBDV

Chicks artificially infected with IBDV were treated with compound Huangjin granular.The results showed as follows： ① The levels of aspartate aminotransferase（AST） and alanine aminotransferase（ALT） in the test group were significantly higher than those in control group（P〈0.05）,Ast/Alt were significantly lower than that of the positive control group（P〈0.01）,and were significantly higher than that of the negative control group（P〈0.05）.②There were significant difference on the contents of TP,ALB and GLO in blood between the test group and negative control group（P〈0.05）.③The mortality of test group were significantly lower than that of positive control group（P〈0.05）,the curative rate and effective rate were 90.0% and 93.3%,respectively.④Chickens survived 7 days after treatment were dissected for observing the extent of bursal damage and the bleeding of muscle,the degree of lesions were also compared.It was showed that damage of Fabricius and the bleeding of muscle were significantly lower than that of the positive control group（P〈0.05）.Compound Huangjin granular could reduce the damage of Fabricius caused by IBDV infection.Conclusion： Compound Huangjin granular composed with Cuscuta chinensis,Fructus lycii,etc.,showed a significant therapeutic effect on chickens artificially infected with IBDV.