Toll样受体及其对肠黏膜免疫的调节作用

Toll样受体(TLRs)是近年来备受关注的一种模式识别受体,在脊椎与非脊椎动物中具有病原体传感器的功能。TLRs对体内外特异性配体的识别是启动先天免疫的基础,并迅速增加对抗入侵病原体的保护性反应,最终激活适应性免疫。TLRs在肠道免疫对病原菌与益生菌的区分过程中发挥重要作用,同时TLRs可调控动物肠道上皮分泌抗菌肽杀灭病原菌,对肠道健康具有积极的作用。本文介绍了TLRs的种类、配体及相应的信号通路,探讨TLRs在肠道免疫调节中的关键作用。

Toll-Like Receptors and Their Regulation Role of Intestinal Mucosal Immunity

Toll-like receptors ( TLRs) are a highly conservative group of pattern recognition receptors, which play roles of pathogen sensors in vertebrate and invertebrate species.Recently, Toll-like receptors have been far and wide concerned.The recognition of TLRs to specific ligands is the basis of the innate immune system, and it enables protective responses to mount rapidly, then, it can activate adaptive immunity against invading patho-gens.TLRs play an important role in the process of distinguishing between the pathogenic bacteria and probiotic for the intestinal immune, while secretion of antimicrobial peptides is also regulated by TLRs in intestinal epi-thelial.This paper introduced the types of TLRs, ligands and the corresponding signal pathway, and discussed the key role of TLRs in intestinal immune regulation.