复方姬松茸多糖口服液对大鼠的慢性毒性试验简

研究旨在观察连续灌胃复方姬松茸多糖口服液对大鼠产生的病理和毒理变化。将80只Wistar大鼠随机分为高、中、低剂量组和溶剂对照组，分别以5.6、2.8、1.4 g/kg复方姬松茸多糖口服液和等体积蒸馏水(NS)对照品对大鼠连续灌胃9周，观察和检测大鼠临床症状、血液学和脏器的病理变化情况。结果显示，在临床症状、病理学检查中各试验组大鼠与对照组均未见明显差异。各组大鼠的体重均未见显著差异(P＞0.05)。3个剂量组中，高剂量组的心脏指数、肝脏指数、肾脏指数和中剂量组的心脏指数、肝脏指数与对照组相比均差异显著(P＜0.05)；高剂量组的WBC、LYM、MID、GRA、PLT和中剂量组的WBC、GRA、PLT与对照组相比均差异显著(P＜0.05)；高剂量组的Cre、TG及中、低剂量的TG与对照组相比均差异显著(P＜0.05)。结果表明，中、低剂量复方姬松茸多糖口服液对大鼠无明显毒副作用。

Chronic Toxicity Experiment of Compound Agaricus blazei Murill Polysaccharide Oral Liquid in Rats

The assay was aimed to study the pathology and toxicology changes of compound Agaricus blazei Murill polysaccharide oral liquid impacting on rats through continuous gavage.Divide rats into high dose group,middle dose group,low dose group and solvent control group.Give rats a continuous gavage for 9 weeks with 5.6,2.8,1.4 g/kg compound Agaricus blazei Murill polysaccharide oral liquid and same capacity of distilled water (NS).Observe and detect the clinical symptoms,hematology,blood biochemical and pathologic changes of viscera of rats.The results were that in the clinical symptoms and pathology,there were no conspicuous differences.In body weight,there were no significant differences among the groups (P＞0.05).Compared with control group,heart index,liver index,kidney index of high dose group, and heart index and liver index of middle dose group all had significant differences (P＜0.05).Compared with control group,WBC,LYM,MID,GRA and PLT of high dose group， and WBC,GRA and PLT of middle dose group all had significant differences (P＜0.05).Compared with control group, Cre and TG of high dose group, and TG of middle and low dose groups all had significant differences (P＜0.05).The results showed that the middle and low dose groups of compound Agaricus blazei Murill polysaccharide oral liquid had no obvious toxicity.