| 魔芋葡甘聚糖药物载体的结构与性能 |
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| 引用本文： | 黄荣勋,庞杰.魔芋葡甘聚糖药物载体的结构与性能[J].福建农业学报,2017,32(3). |
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| 作者姓名： | 黄荣勋 庞杰 |
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| 作者单位： | 福建农林大学食品科学学院,福建 福州,350002 |
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| 摘 要： | 为了分析魔芋葡甘聚糖(KGM)作为药物载体材料的结构特征及性能关系,通过复配方法制成KGM/CMC-Na、KGM/SAA、KGM/CMC-Na/SAA药物载体,进行孔隙率、电镜表征等方面的分析,并采用红外光谱分析其稳定性。试验结果:KGM/SAA、KGM/CMC-Na的复配能够起到协同增效的作用;KGM/SAA比KGM/CMC-Na、KGM/SAA/CMC-Na更为稳定;KGM/SAA药物载体的孔隙率较高,为73.00%;KGM/SAA药物载体的粒径大约为0.31~0.38mm,大小分布较为均匀。结果表明KGM/CMC-Na、KGM/SAA、KGM/CMC-Na/SAA中KGM/SAA最适宜作为药物载体。
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| 关 键 词： | 魔芋葡甘聚糖 黏度 红外光谱 扫描电镜 |
The Structure and Properties of Konjac Glucomannan Drug Carrier |
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| HUANG Rong-xun,PANG Jie.The Structure and Properties of Konjac Glucomannan Drug Carrier[J].Fujian Journal of Agricultural Sciences,2017,32(3). |
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| Authors: | HUANG Rong-xun PANG Jie |
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| Abstract: | To analyze the structural characteristics and properties of Konjac Glucomannan (KGM) as drug carrier.Methods KGM/CMC-Na,KGM/SAA and KGM/CMC-Na/SAA drug carriers were prepared by complex method,and were analyzed with the porosity and electron microscopy.Infrared spectroscopy was used to analyze its stability.Results The combination of KGM/SAA and KGM/CMC-Na can play a synergistic effect;KGM/SAA is more stable than KGM/CMC-Na and KGM/SAA/CMC-Na;KGM/SAA is higher porosity,and its drug capacities is 73%;the particle size of KGM/SAA drug carrier is about 0.31~0.38mm,and uniform distribution.Conclusion KGM/SAA is the most suitable as drug carriers in three samples. |
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| Keywords: | Konjac Glucomannan Viscosity Infrared Spectrum Scanning Electron Microscope |
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