羊水来源干细胞基因组特征的研究进展

人和动物存在羊水来源的多潜能干细胞(amniotic fluid-derived stem cells,AFSCs)。AFSCs被公认为是介于胚胎干细胞和成体干细胞之间的一种特殊的细胞类型,因此,AFSCs同时具有成体干细胞和胚胎干细胞的生物学特性。AFSCs干细胞特性的保持是以其标志基因以及基因组的整体特异表达为基础。目前,已经有相关研究对不同胎龄时期的AFSCs的标志基因Oct4、Sox2、Nanog、SSEA系列以及Tra-1-60和Tra-1-81等在基因组中的表达特征进行了分析。对AFSCs的相关研究进展进行综述,以期为羊水干细胞的进一步系统、深入研究提供理论依据。

Research Progress on Genome Characteristics of Amnionic Fluid Stem Cells

Amniotic fluid-derived stem cells （AFSCs） exist in the amnionic fluid of human and animals. AFSCs are generally acknowledged as a special cell type between embryo stem cells （ESCs） and adult stem cells （ASCs）, thereby, they have the biological characteristics of embryo stem cells and adult stem cells. The keeping of AFSCs characteristics is based on the whole specific expression of its marker gene and genome. At present some marker genes of AFSCs at different gestational ages like Oct4, Sox2, Nanog and SSEA have been studied, and expression characteristics of Tra-1-60 and Tra-1-81 in genome have been analyzed. Research progress on AFSCs was summarized to provide reference for research on amnionic fluid stem cells.