C3 fixed in vivo to cornea from horses inoculated with Leptospira interrogans. |
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| Authors: | A E Parma S I Cerone S A Sansinanea M Ghezzi |
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| Affiliation: | Lab. Inmunoquimica y Biotecnologia, Facultad Cs. Veterinarias, Univ. Nac. del Centro PBA, Tandil, Argentina. |
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| Abstract: | C3 was detected bound in vivo to the opaque cornea of horses inoculated with killed Leptospira interrogans. Employing epithelial corneal cells isolated from a monolayer in tissue culture, we proved that C3 is fixed in vitro to the intact cell surface after incubation with a fresh equine anti-Leptospira serum. These findings, in addition to the infiltration of cornea with neutrophils and lymphocytes, may explain the mechanisms of tissue damage in recurrent uveitis of horses with leptospirosis. |
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