Modification of catecholamine metabolism in rats by magnesium aspartate hydrochloride |
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| Authors: | M Kietzmann M Kreisner |
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| Institution: | Institut für Pharmakologie, Toxikologie und Pharmazie, Tier?rztlichen Hochschule, Hannover. |
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| Abstract: | The metabolism of catecholamines was studied in rats treated with magnesium aspartate hydrochloride (MAH). For 3 days, MAH was administered via food (1000 mg magnesium/kg food). An enhanced renal elimination of catecholamine metabolites was found in MAH-treated rats as well as in rats stressed by immobilisation. Measured in vitro, hepatic monoaminoxidase activity was enhanced. The catechol-O-methyltransferase activity was not altered. In conclusion, oral treatment with MAH is followed by enhanced hepatic metabolism and increased renal elimination of catecholamines. |
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