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微波辐射下香豆素基缩氨基硫脲化合物的合成和抑菌活性研究
引用本文:徐翠莲,宛新生,党玉丽,苏惠,姜志红,周占芳,王喜云,邓曙光. 微波辐射下香豆素基缩氨基硫脲化合物的合成和抑菌活性研究[J]. 河南农业大学学报, 2009, 43(1)
作者姓名:徐翠莲  宛新生  党玉丽  苏惠  姜志红  周占芳  王喜云  邓曙光
作者单位:河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002;河南农业大学理学院,河南,郑州,450002
摘    要:从含不同取代基的水杨醛与乙酰乙酸乙酯出发,利用微波法合成了一系列新的含有香豆素骨架的缩氨基硫脲类化合物.首先水杨醛与乙酰乙酸乙酯反应得到一系列乙酰基香豆素中间体,然后使之在微波加热条件下与氨基硫脲发生缩合反应得到含有香豆素骨架的缩氨基硫脲化合物,目标化合物的结构均经IR,1H NMR进行了表征.选择2种有害菌对其抑菌活性检测,结果表明,该合成物对测试菌种具有优良的抑制效果,抑菌活性从大到小的顺序是:3b>3e>3c>3f>3d>3a.

关 键 词:缩氨基硫脲  香豆素基  微波辐射  合成  抑菌活性

Microwave-induced synthesis and antibacterial activity of thiosemicarbazone compounds based on coumarin-skeleton
XU Cui-lian,WAN Xin-sheng,DANG Yu-li,SU Hui,JIANG Zhi-hong,ZHOU Zhan-fang,WANG Xi-yun,DENG Shu-guang. Microwave-induced synthesis and antibacterial activity of thiosemicarbazone compounds based on coumarin-skeleton[J]. Journal of Henan Agricultural University, 2009, 43(1)
Authors:XU Cui-lian  WAN Xin-sheng  DANG Yu-li  SU Hui  JIANG Zhi-hong  ZHOU Zhan-fang  WANG Xi-yun  DENG Shu-guang
Affiliation:College of Sciences;Henan Agricultural University;Zhengzhou 450002;China
Abstract:A series of new thiosemicarbazones compounds with coumarin-skeleton were synthesized from salicylaldehyde with various substituts and ethylacetoacetate.First,acetyl coumarin intermiediates were obtained from different salicylaldehydes and ethylacetoacetate,and then thiosemicarbazones were prepared by the reaction of acetyl coumarins with aminothoiurea.The structures of the target chemicals had been both characterized by IR and 1H NMR.The bioactivity test showed that these compounds possessed good antimicrob...
Keywords:thiosemicarbazone  coumarin-skeleton  microwave-induced  synthesis  antibacterial activity  
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