Elevated Serum Anti-Müllerian Hormone in an Arabian Mare with Granulosa Cell Tumor |
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Authors: | Faramarz Gharagozlou Reza Youssefi Vahid Akbarinejad Javad Ashrafihelan |
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Institution: | 1. Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;2. Theriogenology Association, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;3. Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran |
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Abstract: | Anti-Müllerian hormone (AMH), produced by granulosa cells, has been reported to be elevated in mares with granulosa cell tumor. A 13-year-old Arabian mare was referred after 3 years of infertility. Rectal and ultrasonographic examination revealed enlargement and multicystic appearance of the left ovary. The mare had substantially higher concentration of AMH (21.6 ng/mL) compared with normal cyclic mares (n = 5; 0.36 ± 0.02 ng/mL). Testosterone (50 pg/mL) concentration was also elevated, but progesterone concentration (0.4 ng/mL) was lowered. Accordingly, the mare was presumptively diagnosed with granulosa-theca cell tumor and a left ovariectomy implemented using ventral midline approach under general anesthesia. Histopathological examination confirmed the diagnosis of granulosa-theca cell tumor. Serum concentrations of AMH decreased to 2 ng/mL and 0.5 ng/mL 2 and 4 weeks after tumor removal, respectively. In conclusion, the current report presents confirmatory evidence that evaluation of serum AMH could be useful for diagnosis of granulosa cell tumor in mare. |
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Keywords: | Anti-Mü llerian hormone Granulosa-theca cell tumor Mare |
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