| 肝素钠对伪狂犬病毒侵染BHK-21细胞和小白鼠的抑制 |
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| 引用本文： | 丁建华,张光道.肝素钠对伪狂犬病毒侵染BHK-21细胞和小白鼠的抑制[J].畜牧与兽医,1998,30(2):51-52. |
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| 作者姓名： | 丁建华 张光道 |
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| 作者单位： | 武汉大学生科院，同济医科大学，延安大学生物系 |
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| 摘 要： | 应用空斑技术，检测肝素钠对伪狂犬病毒（ＰＲＶ）在ＢＨＫ＿２１细胞上形成空斑的数量，证实肝素钠对ＰＲＶ的感染能力有较大抑制作用。小鼠试验证实肝素钠可降低病毒的致病力，但肝素钠对小鼠有一定毒性。
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| 关 键 词： | 伪狂犬病毒 肝素钠 空斑试验 |
THE EFFECT OF HEPARIN ON THE INFECTION OF PSEUDORABIES VIRUS(PRV) TO BHK_21 CELLS AND MOUSE |
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| Ding Jianhua,Qu Zhaoxia et al.THE EFFECT OF HEPARIN ON THE INFECTION OF PSEUDORABIES VIRUS(PRV) TO BHK_21 CELLS AND MOUSE[J].Animal Husbandry & Veterinary Medicine,1998,30(2):51-52. |
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| Authors: | Ding Jianhua Qu Zhaoxia |
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| Institution: | Wuhan University 430072 |
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| Abstract: | To determine the effect of heparin on the infection of PRV to BHK_21 cells and mouse,the number of plaques formed and protection of mouse from PRV challenge were investigated.At concentration of 0.01μg/ml,heparin had an inhibitory effect on the infection of PRV to BHK_21 cells.The higher the concentration,the stronger inhibition potency was manifested.When the concentration was 10μg/ml,the inhibition rate reached 97.4%.Likewise,heparin could inhibit the infection of PRV to mouse.The suitable concentration was 5μg/ml.While 10μg/ml at a dose of 0.2ml was lethal to mouse. |
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| Keywords: | pseudorabies virus(PRV) glycoprotein C(gC) heparin |
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