青春期双酚A暴露对CD-1小鼠种属行为的影响

利用储藏、挖掘和作窝实验检测青春期暴露双酚A（BPA）对老年CD-1小鼠种属行为的影响。结果显示老年对照组的储藏、挖掘和做窝能力均较青年对照组下降（P<0.05）。BPA处理高剂量组和低剂量组雌鼠的储藏能力都较老年对照雌鼠下降（P<0.05），高剂量组总体及雌鼠的挖掘能力显著低于相应对照（P<0.05）。上述结果提示老年CD-1小鼠可能具有普遍性种属行为抑制，青春期BPA暴露对于老年CD-1小鼠种属行为有性别和任务特异性损害作用。

Effects of adolescent exposure to bisphenol A on species-typical behaviors in the aged CD-1 mice

In this study, the tasks of hording, burrowing, and nesting were used to evaluate the effect of adolescent bisphenol A exposure on the species-typical behaviors in the aged CD-1 mice. The results showed that the abilities of hording, burrowing, and nesting in the old group significantly reduced (Ps < 0.05) compared to the young group. The hording abilities significantly reduced in the females exposed to a high- and low-dose BPA during puberty compared to the corresponding old controls (P < 0.05). The overall performance of the burrowing abilities in the high-dose group and the females significantly decreased than those in the corresponding controls (Ps < 0.05). These results suggested that old CD-1 mice might have a general species-typical behavioral inhibition. Adolescent exposure to BPA could impair the species-typical behaviors in the CD-1 mice in a gender-and task-specific manner.