Antineoplastic activity of selected constituents of Duguetia glabriuscula |
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| Authors: | Matos M F C Leite L I S P Brustolim D de Siqueira J M Carollo C A Hellmann A R Pereira N F G da Silva D B |
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| Institution: | Laboratório de Culturas Celulares, Departamento de Farmácia-Bioquímica, Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil. mfcmatos@nin.ufms.br |
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| Abstract: | The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep2 human larynx carcinoma cells. The cytotoxicity exhibited by beta-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14beta-diol caused inhibition of cellular growth with IC50 values lower than 25 microg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive. |
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| Keywords: | Duguetia glabriuscula Cytotoxicity β-Sitosterol Sesquiterpenes Polycarpol |
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